|
| |
 | Chemical Structure |
|
 |
| Chemical Formula |
|
C36H61O11Na |
| Molecular Weight: |
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|
| Cas No.: |
|
17090-79-8
|
| Synonyms |
|
2-[2-Ethyloctahydro-3'-methyl-5'-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran-5-yl]]-9-hydroxy-ß-methoxy-a,?,2,8-t,
63714, A-3823A, monensic acid, Monensin, Romensin |
| Compliance |
|
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| Description |
|
MONENSIN is the polyether ionophore antibiotic, which is produced by
fermentation of Streptomyces cinnamonensis. It is active against certain
gram-positive microorganisms primarily against coccidia, such as Eimeria
acervulina, E. mivat, E. brunetti, E. maxima, E. necatrix, E. tenella in
broiler chickens.
MONENSIN acts on the trophozoite in the first cycle of schizogony. The
mechanism by which MONENSIN acts is based on its ability to form complexes
with sodium and potassium ions and to prevent penetration across the cell
membrane of coccidia. MONENSIN prevents sodium transport while potassium is
accumulated in the cell of the parasite thereby inhibiting mitochondrial
functions of the parasite, oxidation and hydrolysis of adenosine
triphosphate.
In ruminants with developed forestomachs MONENSIN increases the rate of
weight gain and enhances feed efficiency.
|
| Indications |
|
1. Prevention of coccidiosis caused by Eimeria
acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix, E. tenella in
broiler chickens. 2. For enchanced feed efficiency and increased rate
of weight gain in young cattle and lambs with developed forestomachs. |
| Specification |
|
Pure,
10% and 20% Premix (Insoluble oral powder). For10% Premix,
each 100g of insoluble powder contains 10 g of monensin (in the form of
sodium salt) and an insoluble carrier. |
| Stability
|
|
Stable under normal storage conditions. Unstable
in contact with acidic and alkaline substances. It maintains its stability
very well for two years when stored under ambient temperature. |
| Dosage & Administration |
|
MONENSIN is intended for use only in ruminants
with fully developed forestomachs. Detailed dosage and administration guide
is as follows:
|
Animal species |
10% premix
|
20% premix
|
Pure Substance |
|
Broiler chickens |
900
- 1100 g/t |
450 - 550 g/t |
90 -
110 g/t |
Turkeys up to
10 weeks of age |
540 - 900 g/t |
270
- 450 g/t |
54 -
90 g/t |
|
Fattening beef cattle |
50
-300 g/t |
25
- 125 g/t |
5
-30 g/t |
|
Fattening lambs |
100g |
50g |
10g/t |
|
Breeding heifers and bulls, body weight over 200 kg |
50-300 g/t |
25-125 g/t |
5
- 30 g/t |
|
Young pasture cattle, body weight over 200 kg |
0.5 -2 g per head per day |
0.25 -1 g per head per day |
0.05 -0.2 g per head per day |
Remarks: The total daily amount of Monensin 10% premix given to cattle
should not be less than 0.5 kg and not more than 3.5 kg per head per day.
Important: must be thoroughly mixed in feeds
before use.
Thoroughly mix 500 g (0.50 kg) of MONENSIN PREMIX in one metric tonne (1000
kg) of feed to provide monensin at 99 g monensin activity per metric tonne
of feed.
It is recommended that MONENSIN PREMIX be mixed with a small quantity of the
finishing feed before it is incorporated in to the bulk of the feed being
prepared.
Broiler chickens - feed the medicated feed continuously as the sole ration
|
| Precautions |
|
1. Do not use this medicated feed for treatment
of outbreaks of coccidiosis.
2. Do not allow canines, horses or other equines, or guinea fowl access to
formulations containing monensin. Ingestion of monensin by these species has
been fatal.
3. Poultry consuming monensin should not be treated with products containing
tiamulin. Severe growth depression may occur.
4. May be used in feeds containing the pellet binding agents bentonite (2%),
Attapulgite (2%), Kaolin (2.5%), Lignin Sulfonate (4%), Carboxy
Methylcellulose (0.1%) or Agri-Colloid.
5. Do not exceed recommended levels as reduced average daily gains may
result |
| Warnings |
|
1. Do not feed to replacement and laying
chickens. Do not use MONENSIN in lactating dairy cows.
2. When mixing and handling MONENSIN PREMIX, use protective clothing,
impervious gloves and a dusk mask. Operators should wash thoroughly with
soap and water after handling.
3. Do not supplement monensin from other sources (eg. other feedstuffs
containing monensin or other slow release devices containing monensin). |
| Toxicity |
|
|
BROILER |
LD50 = 200 mg/kg LW.
1.5 to 2 times the usual dose
for 3 weeks = loss of weight.
3 to 6 times the usual dose =
reduction of the daily weight gain, feed consumption, mortality.
Decrease of water
consumption.
In warm circumstances :
reduction of feed consumption. |
|
LAYING AND BREEDER PULLET |
Authorised for growing
breeder hens. |
|
LAYING HEN |
Residue in the eggs. |
|
BREEDER HEN |
At 100 ppm reduction of
fertility (Jones – 1990). |
|
TURKEY |
LD50
= 335 mg/kg
LW
for the young ones.
200 – 300 ppm at 7-8 weeks :
decrease of weight and of the feed consumption from 13 to 24% (Potter &
al –1986)
For the full grown : <100 ppm
continuously = mortality (Halvorsen & al – 1982) |
|
DUCK |
No
negative results at 2 times of the
usual broiler
dose (Perlstein –1984), paralysis at 158 ppm for the Pékin
duck(Reece
– 1988). |
|
GUINEA FOWL |
Paralysis, mortality at
the
usual
broiler
dose (Reece – 1988). |
|
PHEASANT |
No
negative results at the
usual
dose (Jurkovic – 1982). |
|
QUAIL |
No
negative results at the
usual
dose. |
|
PARTRIDGE |
No
negative results at the
usual
dose. |
|
RABBIT |
Toxic at 100 ppm. LD50
= 40 mg/kg
LW. |
|
HORSE |
DLD50
= 2 mg/kg
LW
(it means 10 kg of a broiler feed for a 500 kg horse).
External signs : ataxia,
paralysis,
salivation,
cardiac
myopathy
, mortality.
|
|
CATTLE |
Authorised.
From 40 to 100 ppm : anorexia, decrease
of growth.
Very high toxic at 6-10 the dose
recommended for cattle.
LD50
= 25 mg/kg
LW. |
|
SHEEP |
LD0*
= 4 mg/kg LW.
During 3 month : 22 ppm
without negative results.
At 66 ppm : 10% of cardiac
injury.
At 110 ppm : 10% of
mortality. |
|
SWINE |
LD50
= 16 – 50 mg/kg LW. |
*LD0=
Minimum fatal
dose at single administration. |
| Packing: |
|
25 Kg Bag in one compound paper
bag with plastic liner inside. Or in 25 Kg fiber drums. |
| Storage |
|
Store in a cool and dry place |
| Shelf Life |
|
2 years. |
| Remarks |
|
In need of further
information, please kindly us at:
biok@vetamo.com or
davidvan2000@homtail.com or call our direct phone: 0086 133 5582 2008 |
|
